Matthew Lew

Professor Lew and his students build advanced imaging systems to study biological and chemical systems at the nanoscale, leveraging innovations in applied optics, classical and quantum detection and estimation theory, optimal system design, and physical chemistry. Their advanced nanoscopes (microscopes with nanometer resolution) visualize the movements of individual molecules inside and outside living cells. Examples of new technologies developed in the Lew Lab include 1) using tiny fluorescent molecules as sensors that detect amyloid aggregates, 2) designing new “lenses” that produce images that capture how molecules move and tumble, and 3) new imaging software that robustly measures the position and orientation of single molecules.